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Poster Design: Tips for Creating a Successful Poster

Font

General guidelines for font and font size. 

1-2 font styles, San Serif

Bold, Italics, Underline (use consistently)

If your conference or event gives different guidelines, use those.

There are no "rules," but it may help to use these dimension guidelines in your software for font size when in doubt about readability:
Title: 80 -150 pts, bolded
Author: 54-60pts
Headings: 36-40pts
Body Text: 24-32pts
Captions: 18 pts

Serif vs. San Serif Font

image source: http://drmarkwomack.com/images/serif-vs-sans-serif.png